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SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).

SAM-e supplements are synthetically derived and sold in the U. Several studies show that SAM-e works as well for depression as some anti-depression medications by increasing serotonin, dopamine, and other “feel good” brain chemicals (12, 13).

Sometimes there are vital synergistic relationships between these various serotonin boosting substances.It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).SAM-e should not be mixed with drugs that affect serotonin release such as levodopa, Demerol, or Ultram, or the over-the-counter cough remedy Robitussin DM (15).All of the B vitamins are needed for a healthy, functioning nervous system and several are needed to synthesize serotonin (16).Here are a few that are integrally connected to serotonin production.

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