She appeared in several television series and commercials, before acquiring her first significant role prior to her 15th birthday, playing Jackie Burkhart on the television series That '70s Show (1998–2006).
Since 1999, she has voiced Meg Griffin on the animated series Family Guy.
Oftentimes with animation they'll have adult actors doing the voices of teenagers and they always sound like Saturday morning voices. She had a very natural quality to Meg that really made what we did with that character kind of really work." In 2001, she appeared in Get Over It opposite Kirsten Dunst.
She followed that up in 2002, by starring in the straight-to-DVD horror film American Psycho 2 alongside William Shatner, a sequel to the 2000 film American Psycho.
The film was directed and co-written by Family Guy creator Seth Mac Farlane.Director Darren Aronofsky cast Kunis in the film based on her performance in Forgetting Sarah Marshall, and on the recommendation of co-star and close friend Natalie Portman.She underwent a training regimen that included cardiovascular exercise, a 1,200-calorie a day diet (she lost 20 pounds that she regained after filming ended), and ballet classes for four hours a day, seven days a week.American Psycho 2 was poorly reviewed by critics, Also in 2008, Kunis portrayed Mona Sax, an assassin, alongside Mark Wahlberg in the action film Max Payne, based on the video game of the same name.Kunis underwent training in guns, boxing, and martial arts for her role.